Cancer Interventions

I began the following research for Arthur, though I keep updating it over the years as I hear new research and as friends’ family members have developed cancer. I’ve been staying up to date on it as the Taves side of the family seem to be prone to developing cancer.

When I entered the mental health field, I realized everything they taught was decades old, I think the medical field has some similarities. Also, many practitioners might not be able to stay up to date on the latest trails. In regards to the researchers I listen to via podcast, they frequently speak to the trials they run will likely never receive enough funding ($50+ million) to get through FDA phase 3 trials, as there’s little money to be made in interventions that are nutritional, emotional, or anything except pharmacological. I’m slightly cynical about trusting my practitioners to stay fully up to date; I believe their hearts are in the right places, yet they have to operate in a difficult and broken system. My understanding is for cancer, the goal is to kill the cancer cells prior to killing the healthy cells, so any interventions that make cancer cells slightly more stressed or healthy cells slightly more robust during the chemotherapy/radiation rounds can make a significant different.  

  • Step 1 – Consult with a Metabolic Oncologist or see if the oncologist can confirm the cancer does not have a BRAV V600E mutation. Only a small amount of cancers have that mutation, and as long as that mutation isn’t present then Fasting/Fast Mimicking/Keto should be extremely advantageous.  The 2016 Nobel Peace Prize for Physiology is about how autophogy breaks down damaged (cancerous) cells first and shrinks tumors. Metabolic oncology is a developing specialty, still very new thoughhttps://www.ncbi.nlm.nih.gov/m/pubmed/25586106/. Some possible questions to ask:
  • What is the primary source of energy for this cancer? Glucose or Ketones
    • Fasting/Fast Mimicking/Keto appears to be beneficial on about 90% of cancers that are glucose dependent for energy. 10% of cancers are metabolic fluid and can use glucose and ketones – I believe the only cancers we know of utilize ketones are ones with BRAF V600E mutation should avoid low-carb diets. This mutation is found in more than 60 percent of melanomas (skin cancer) and all of the hairy cell type of leukemia (bone marrow), as well as a subset of colorectal (colon and rectum) cancers (10 percent) and multiple myelomas (bone marrow) (5 percent). I didn’t see anything about ovarian cancer.
  • If the cancer is metabolically fluid would fasting/fast mimicking/keto provide protection from the negative side effects of radiation and/or chemotherapy (possibly via increasing the robustness of healthy cells)?
    • Some studies are showing minimal nausea symptoms and lethargy, while maintaining weight when undergoing chemotherapy/radiation and on a fast mimicking/keto diet.  
      • https://www.foundmyfitness.com/episodes/guido-kroemer
      • Anyway You Can, speaks about a famous oncology clinic that requires all patients to be in ketosis for 2 week prior to beginning chemotherapy
      • What diet intervention do you recommend?
        • Dr Longo developed the five phase chemotherapy diet, which is in trial. He speaks some about a diet here:https://valterlongo.com/cancer/
          • FOLLOW THE LONGEVITY DIET (book being sent to you) Follow the Longevity Diet with protein intake reduced to the lower range of about 0.31 grams per pound of body weight per day. Confine all eating to within a twelve-hour period; for example, start after 8 a.m. and end before 8 p.m. Don’t eat anything within three to four hours of bedtime.
          • PLANT BASED FOODS WITH LIMITED FISH – Limit fish intake to one or two times a week; otherwise, stick to plant-based foods.
          • REDUCE SUGARS – Reduce sugars to very low levels. Also minimize the consumption of pasta and breads. Keep blood-sugar levels as low as possible within the safe range.
          • HEALTHY WEIGHT – Maintain a healthy weight and BMI.
          • EXERCISE – Exercise regularly – (especially before or immediately after any any type of carbs – this allows the glucose to replenish the energy in your muscles and not feed the cancer)
          • FIVE DAY FAST Undergo a five-day FMD (fast mimicking diet) every one-to-three months, depending on your weight and health status.  In mouse studies, FMD was as effective as chemotherapy. Instead of damaging normal tissues and organs, it protected them.
          • VITAMINS – Nourish yourself with essential fatty acids (omega-3 and omega-6), vitamins, and minerals from a variety of vegetables (broccoli, carrots, green peppers, tomatoes, garbanzo beans, lentils, peas, black beans, etc.) and fish (salmon, anchovies). Your immune system is one of the major defenses against cancer. The diet must be balanced to kill cancerous or precancerous cells without causing deficiencies in your immune system or hormonal changes that can make you frail.
          • VITAMIN C – Discuss with your oncologist the option of taking 6 grams of vitamin C or Ester-C® daily for a few weeks every six months. Multiple studies have demonstrated vitamin C to possess cancer-fighting properties, although its effectiveness in preventing cancer is controversial. Taken at this level for a few weeks every six months, vitamin C is not known to have major side effects. The patient and doctor may also consider continuing high level vitamin C consumption for longer periods.
          • GOOD FATS – Consume plenty of good fats from olive oil, nuts, and fish, but minimize saturated fats, even those that are vegetable-derived.
          • AVOID ALCOHOL – Consume as little alcohol as possible.
        • Fasting for Cancer: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2370-6
  • What other interventions are recommended?
    • Don D’Agostino – The metabolic management of cancer with a Press-Pulse approach [1:59:45]; https://itunes.apple.com/us/podcast/the-peter-attia-drive/id1400828889?mt=2&i=1000415911177
      • One of his recommendations includes hyperbolic chamber, I thought Denver Recovery Center used to include this in their services, yet I no longer see it offered. They have an unlimited monthly pass, so that could be an affordable way to get sessions if they do have it.
  • There was a trial for high dose vitamin C for 6 weeks, I don’t remember when the 6 weeks of high dose vitamin C is in timing to the chemo. A few researchers have mentioned stopping all non-food based antioxidants as it provides a protection mechanism to the cancer cells prior to chemo/radiation, though the trial was to see if the high dose acts as a stressor to the cancer cells more than healthy cells

Step 2 – If the Metabolic Oncologist recommends a keto/fasting/fast mimicking strategy, read Anyway You Can and implement it asap. It’s by a PCP and not a researcher, so the data is older and the author doesn’t cover the risks or when the diet would be counter-indicated, thus why consulting with the Metabolic Oncologist or asking the oncologist about the mutation first before engaging in the diet.

Resources:

  • If you want more information, I think some main researchers on dietary interventions are:
  • Don D’Agostino, PhD awesome researcher for NASA and Navy Seal stuff (doesn’t have his own podcast yet if you go to his website he’s been on a guest on about 50 podcasts)
  • Dr Valter Longo
  • Dr Satchin Panda
  • Check out the psilocybin assisted psychotherapy trials. Reducing stress, anxiety, and fear seem to have a massive robustness effect on healthy cells. I’m willing to guide or maybe Kacy would prefer a friend like Annie. German New Medicine hypothesizes most cancers have connections to unprocessed emotional traumas. More than half of the participants in the psilocybin assisted psychotherapy trials, all of which were diagnosed as terminal, are still alive and many are in full remission, so this seems likely to be supportive intervention.
  • Turkey Tail Protocol

Other Research:

  1. Starvation, Stress Resistance, and Cancer – Cell Press 2018  PDF
  2. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer
    and Chemotoxic Resistance in Aged Mice – Scientific Reports 2017  PDF
  3. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy – Plos 2017  PDF
  4. Protective effects of short-term dietary restriction in surgical stress and chemotherapy – Elsevier 2017  PDF
  5. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions – American Association for Cancer Research 2016  PDF
  6. Safety and feasibility of fasting in combination with platinum-based chemotherapy – BioMed Central  2016  PDF
  7. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity – Cancer Cell 2016  PDF
  8. Fasting and Caloric Restriction in Cancer Prevention and Treatment – 2016   PDF
  9. Growth factors, aging and age-related diseases – Elsevier 2016  PDF
  10. 10.Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition – Oncotarget 2015  PDF
  11. Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models – Oncotarget 2015  PDF
  12. 12.Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression – Elsevier 2013  PDF
  13. 13.A small group of Ecuadorians with a rare genetic disorder could hold a key to cancer and other age-related illness – Discover 2013  PDF
  14. 14.Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer – 2013  PDF
  15. 15.Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy – Science Translational Medicines 2012  PDF
  16. 16.Starvation, detoxification, and multi-drug resistance in cancer therapy – Elsevier 2012  PDF
  17. 17.Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy – Plos 2012  PDF
  18. 18.Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients – NPG 2011  PDF
  19. 19.Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model – Jove 2011  PDF
  20. 20.Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index – Cancer Research 2010  PDF
  21. 21.Fasting and cancer treatment in humans: A case series report – Impact Aging 2009  PDF
  22. 22.Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy – PNAS  PDF
  23. 23.Turning anti-ageing genes against cancer – Nature Reviews 2008  PDF
  24. 24.Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system –  The Journal of Cell Biology 2008  PDF
  25. 25.A simple model system for age-dependent DNA damage and cancer – Elsevier 2007  PDF